Kinetic studies of tyrosine kinase inhibition by erbstatin.
نویسندگان
چکیده
منابع مشابه
Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase.
The role of tyrosine kinases in the responses of human neutrophils to chemotactic factors was examined using the recently described inhibitor erbstatin. Pre-incubation with erbstatin decreased the amount of tyrosine phosphorylation induced by the formylated oligopeptide formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) without effecting the binding of [3H]-fMet-Leu-Phe. Erbstatin also dose-d...
متن کاملInhibition of tyrosine kinase and src oncogene functions by stable erbstatin analogues.
growth of humanbreast carcinoma MCF-7transplanted in nude mice5). However, it is unstable and easily degraded in serum6) and in cell culture medium (K. Umezawa; unpublished results). Therefore, we synthesized methyl 2,5-dihydroxycinnamate (2,5-MeC) as a stable analogue of erbstatin3). It inhibited EGF-induced S-phase entry3), cellular src functions4), and in vivo growth of MCF-7tumors (Dr. M. T...
متن کاملInhibition of RET tyrosine kinase by SU5416.
Thyroid neoplasia is frequently associated with rearranged during transfection (RET) proto-oncogene mutations that cause hyperactivation of RET kinase activity. Selective inhibition of RET-mediated signaling should lead to an efficacious therapy. SU5416 is a potent inhibitor of vascular endothelial cell growth factor receptor, c-Kit, and FLT-3 receptor tyrosine kinases presently used in clinica...
متن کاملIn- vitro studies of anti-EGFR tyrosine kinase activity of Thai nutraceutical plants
Functional foods have emerged as a new approach to improve human health in term of nutraceutical to prevent people from illness rather than cure patients though medical treatment. In Asian society, particularly in Thailand, the utilizations of functional ingredients have been integrated in every parts of ordinary life. In this study, the tyrosine kinase activity of epidermal growth factor recep...
متن کاملIn- vitro studies of anti-EGFR tyrosine kinase activity of Thai nutraceutical plants
Functional foods have emerged as a new approach to improve human health in term of nutraceutical to prevent people from illness rather than cure patients though medical treatment. In Asian society, particularly in Thailand, the utilizations of functional ingredients have been integrated in every parts of ordinary life. In this study, the tyrosine kinase activity of epidermal growth factor recep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1987
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.40.1471